The association of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) K121Q gene polymorphism with the risk of type 2 diabetes mellitus in European, American, and African populations: a meta-analysis

Authors

  • Jonny Karunia Fajar Medical Research Unit, School of medicine, Syiah Kuala University, Banda Aceh, Indonesia

DOI:

https://doi.org/10.17532/jhsci.2016.358

Keywords:

ENPP1 K121Q gene polymorphism, type 2 diabetes mellitus, genetic polymorphism, meta analysis, insulin resistance.

Abstract

Introduction: Several studies regarding the association of the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) K121Q gene polymorphism with the risk of type 2 diabetes mellitus (T2DM) showed inconsistent results. This study aimed to investigate the association of ENPP1 K121Q gene polymorphism with T2DM risk using meta-analysis. The study was limited to the American, European, and African populations.

Methods: PubMed and Embase databases were searched for eligible publications. The following information was extracted from each study: name of first author, publication year, country of origin, sample size of cases and controls, and size of each allele. The combined odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between ENPP1 K121Q gene polymorphism and T2DM risk were assessed using random or fixed effect model. A comprehensive meta-analysis (CMA) 2.0 was used to analyze the data.

Results: Nineteen studies (17717 cases/28022 controls) on the association between ENPP1 K121Q gene polymorphism and T2DM risk were included in this meta-analysis. The results indicated that the ENPP1 K121Q gene polymorphism was associated with increased T2DM risk (Q vs. K genetic model, OR 95% CI = 1.11 [1.02–1.22], p = 0.014; QQ vs. KK + KQ, OR 95% CI = 1.14 [1.01–1.23], p = 0.039) and decreased T2DM risk (K vs. Q, OR 95% CI = 0.90 [0.82–1.00], p = 0.014; KK vs. KQ + QQ, OR 95% CI = 0.89 [0.80–0.98], p = 0.024).

Conclusions: The results indicate that the ENPP1 K121Q gene polymorphism is associated with the risk of T2DM in the American, European, and African populations.

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Author Biography

Jonny Karunia Fajar, Medical Research Unit, School of medicine, Syiah Kuala University, Banda Aceh, Indonesia

Medical Research Unit, School of medicine, Syiah Kuala University, Banda Aceh, Indonesia

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Published

22-07-2016

How to Cite

1.
Fajar JK. The association of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) K121Q gene polymorphism with the risk of type 2 diabetes mellitus in European, American, and African populations: a meta-analysis. JHSCI [Internet]. 2016 Jul. 22 [cited 2024 Mar. 29];6(2):76-8. Available from: https://www.jhsci.ba/ojs/index.php/jhsci/article/view/540

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