The efficacy and safety of autologous activated platelet-rich plasma therapy as adjuvant treatment of atopic dermatitis in pregnant woman

Authors

  • Karina Karina Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia; HayandraLab, Hayandra Peduli Foundation, Jakarta, Indonesia; Research Center for Regenerative Medicine and Neuroscience, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia
  • Anggara Mahardika Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia
  • Grady Krisandi HayandraLab, Hayandra Peduli Foundation, Jakarta, Indonesia; 4Faculty of Medicine, University of Indonesia, Jakarta, Indonesia https://orcid.org/0000-0002-2016-8420
  • Imam Rosadi Hayandra Lab, Hayandra Peduli Foundation, Jakarta, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Mulawarman University, Samarinda, Indonesia
  • Ratna Purwoko Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia
  • Sarah Listyo Astuti Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia
  • Diani Nazma Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia; Department of Anesthesiology, Faculty of Medicine, Trisakti University, Jakarta, Indonesia
  • Louis Martin Christoffel Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia
  • Meliana Siswanto Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia
  • Johannes Albert Biben Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia
  • Krista Ekaputri Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia
  • Kuswan Ambar Pamungkas Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia; Faculty of Medicine, University of Riau, Riau, Indonesia
  • Tommy P. Sibuea Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Christian University of Indonesia, Jakarta, Indonesia
  • Azza Maryam Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia

DOI:

https://doi.org/10.17532/jhsci.2023.2178

Keywords:

atopic dermatitis, platelet-rich plasma, treatment

Abstract

Introduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder which involves skin barrier and immune dysregulation. The management of AD involves the use of moisturizers and immunosuppressant which are only used for temporary symptom relief and may potentially harm the fetal growth. Autologous activated platelet-rich plasma (aaPRP) is a potential adjuvant treatment for symptom control in pregnant AD patient. This report examines a case of a pregnant patient with AD treated with aaPRP and the monitoring of fetal growth until birth.

Case Report: A 37-year-old pregnant patient with a history of AD when in contact with latex or consumption of dairy products came to Hayandra Clinic. As she had been working as anesthesiologist continuously in contact with latex gloves, she underwent routine aaPRP therapy for 3 years and had 15 aaPRP treatments over the course of her pregnancy. The patient had lesser lesions when AD was induced, no exacerbation of symptoms during pregnancy, and the baby was healthy during pregnancy to birth.

Conclusion: The use of aaPRP therapy for the management of AD may be indicated as it controls the symptoms yet is safe for the patient during pregnancy. There was also no harm effect showing on the fetal development. A larger study such as randomized controlled trial is required to evaluate our findings.


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Published

30.09.2023

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Section

Case reports

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How to Cite

1.
The efficacy and safety of autologous activated platelet-rich plasma therapy as adjuvant treatment of atopic dermatitis in pregnant woman. JHSCI [Internet]. 2023 Sep. 30 [cited 2024 May 24];13(2):129-31. Available from: https://www.jhsci.ba/ojs/index.php/jhsci/article/view/2178