Estimating neonatal screening for congenital hypothyroidism test performance

Authors

  • Emina Hadžimuratović Department of Neonatology, Pediatric Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina https://orcid.org/0000-0002-3745-6832
  • Suada Branković Department of Nursing, Faculty of Health Studies, Univerisity of Sarajevo, Sarajevo, Bosnia and Herzegovina
  • Admir Hadžimuratović Department of Nephrology, Pediatric Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
  • Sniježana Hasanbegović Department of Endocrinology, Pediatric Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
  • Irmina Sefić-Pašić Department of Pediatric Radiology, Radiology Clinic, Clinical Center University of Sarajevo, Bosnia and Herzegovina
  • Džan Ahmed Jesenković Deparment of Epidemiology and Biostatistics, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina https://orcid.org/0000-0001-7238-7687
  • Amila Hadžimuratović Pediatric Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina https://orcid.org/0000-0001-7607-5429
  • Emina Opanković Department for Radionuclide Therapy, Clinic of Nuclear Medicine and Endocrinology, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina https://orcid.org/0000-0002-4903-5234
  • Amila Agić Public Health Center, Sarajevo, Bosnia and Herzegovina https://orcid.org/0000-0001-5964-137X

DOI:

https://doi.org/10.17532/jhsci.2022.1638

Keywords:

Congenital hypothyroidism, Neonatal screening, Thyrotropin

Abstract

Introduction: Newborn screening (NBS) is a system of organized search in the entire neonatal population for specific diseases. In Bosnia and Herzegovina, two diseases are included in NBS, congenital hypothyroidism (CH), and phenylketonuria. The screening for CH is based on determination of thyroid stimulating hormone (TSH) levels in blood obtained by heel prick method. The aim of this study is to evaluate the effectiveness of NBS program for CH based on TSH and establish the mean age of diagnosis of CH.
Methods: TSH was measured by time-resolved fluoroimmunoassay (DELFIA Neonatal hTSH kit). The TSH cutoff value was 9 μU/mL. Neonates with TSH < 9 μU/mL had a negative NBS result. Neonates with TSH ≥ 9 μU/mL were recalled for a confirmation test and thyroid hormones were determined from venous blood to establish diagnosis of CH.
Results: A total of 24,351 neonates were subjected to NBS in our institution. A total of 164 newborns with TSH ≥ 9 μU/ml were sent to additional testing (mean recall rate of 0.68%) at a mean age of 11.4 ± 0.5 days of life. In this group, diagnosis of CH was confirmed in 22 neonates (13.41%). The mean rate of false positive results of NBS was 0.59%. The incidence of CH in Sarajevo Canton ranged from 1/2477 in 2018 to 1/641 in 2020. The mean incidence of CH over a 5-year period was 1/1085, while the mean age at the time of diagnosis was 16.5 ± 1.2 days.
Conclusion: The analysis of NBS on congenital hypothyroidism data showed the satisfactory recall and false positive rate and indicated well selected TSH cutoff value. The mean age at the time of diagnosis assures early treatment and good neurological outcome in neonates with CH.


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Published

26.04.2022

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Research articles

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How to Cite

1.
Estimating neonatal screening for congenital hypothyroidism test performance. JHSCI [Internet]. 2022 Apr. 26 [cited 2024 Oct. 14];12(1):38-40. Available from: https://www.jhsci.ba/ojs/index.php/jhsci/article/view/1638