N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy

Authors

  • Mia Elhidsi Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
  • Fanny Fachrucha Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia https://orcid.org/0000-0001-9450-2180
  • Rizky Yudha Irawan Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia https://orcid.org/0000-0003-4187-919X

DOI:

https://doi.org/10.17532/jhsci.2020.1156

Keywords:

antioxidant, COVID-19, glutathione, N-acetylcysteine, oxidative stress

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection or known as coronavirus disease 2019 (COVID-19) is a highly infectious disease that has been declared as a world pandemic by WHO. Although the majority of patients only experience mild symptoms, older patients and those with comorbidities are in the risk of falling into critically ill and even death. This is thought to correlate with systemic inflammatory response and oxidative stress imbalance. N-acetylcysteine (NAC) is recognized as a potent mucolytic, yet its lesser-known function as an antioxidant is a precursor of glutathione. Basic aspects and either in vivo or in vitro studies showed various mechanisms of NAC acting as a counterbalance in viral infections and its role in decreasing inflammation and oxidative stress. High-dose NAC is reported to be effective as an antioxidant in pneumonia, influenza, sepsis, and acute respiratory distress syndrome. Early evidence in COVID-19 patients showed that NAC could be beneficial. This review gives the scientific background in considering NAC as an adjuvant treatment for COVID-19.

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Author Biographies

Mia Elhidsi, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia

Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia

Persahabatan National Respiratory Referral Hospital, Jakarta

Staff of COVID-19 Task Force, Indonesian Society of Respirology

Consultant of Respiratory Critical Care

Fanny Fachrucha, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia

Division of Immunology

Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia - Persahabatan National Respiratory Referral Hospital, Jakarta

Staff of COVID-19 Task Force, Indonesian Society of Respirology

Consultant of Pulmonary Immunology

Rizky Yudha Irawan, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia

Faculty of Medicine, Universitas Indonesia - Persahabatan National Respiratory Referral Hospital, Jakarta.

Fellowship at Pulmonary and Respiratory Medicine, Universitas Indonesia

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Published

2021-01-07

How to Cite

Elhidsi, M., Fachrucha, F., & Yudha Irawan , R. (2021). N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy. Journal of Health Sciences, 11(1), 1–6. https://doi.org/10.17532/jhsci.2020.1156

Issue

Section

Reviews