Effect of Costus igneus: The insulin plant, on prediabetes and diabetes in neonatal streptozotocin rats

  • Murthy EGK Talasila Bapatla College of Pharmacy
  • Hemalatha Bavirisetti Bapatla College of Pharmacy
  • Jithendra Chimakurthy Bapatla College of Pharmacy
  • Mayuren Candasamy International Medical University

Abstract

Introduction: Pre-diabetes is a condition that persists for a considerable duration before progressing into type 2 diabetes mellitus (T2DM). Development of resistance to insulin is the underlying cause of pre-diabetes, preventive measures such as diagnosis, treatment and exercise will preclude its development into T2DM. The present study aims at studying the effect of pre-treatment and post-treatment with isolated fraction of Costus igneus on pre-diabetes and diabetes in neonatal streptozotocin (STZ) induced T2DM.

Methods: Neonatal rats were treated with STZ and differentiated for pre-treatment and post-treatment. Rats of pre-treated group were treated with isolated fraction of Costus igneus (CIF) from 4th week after STZ administration and after 12th week in non-treated rats of post-treatment group. The antihyperglycemic was studied on 7th and 12th week after STZ treatment using oral glucose tolerance test and the hypoglycemic effect was studied on day 1, 7, 14 and 21 of treatment after 12th week of STZ treatment in both pre and post treated groups.

Results: Oral glucose tolerance test on 7th and 12th week had shown a protective effect against increase in blood glucose levels in pre-treated groups whereas, no such significant decrease was observed in non-treated groups. In the effect on hypoglycemia, a reduction in blood glucose levels was observed on treatment with CIF in both pre and post treated rats on 14th and 21st day.

Conclusions: Treatment with CIF in pre-diabetic stage could reduce the chances of progression into T2DM and is also beneficial in diabetic rats, which could be due to increase in the peripheral utilization of glucose and the insulin mimetic effect of Costus igneus.

Author Biographies

Murthy EGK Talasila, Bapatla College of Pharmacy

Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh - 522101

Hemalatha Bavirisetti, Bapatla College of Pharmacy
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh - 522101
Jithendra Chimakurthy, Bapatla College of Pharmacy
Department of Pharmacology, Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh - 522101
Mayuren Candasamy, International Medical University
Department of Life Sciences, International Medical University, Kualalumpur, Malaysia.

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Published
2014-12-26
How to Cite
TALASILA, Murthy EGK et al. Effect of Costus igneus: The insulin plant, on prediabetes and diabetes in neonatal streptozotocin rats. Journal of Health Sciences, [S.l.], v. 4, n. 3, p. 162-168, dec. 2014. ISSN 1986-8049. Available at: <http://www.jhsci.ba/OJS/index.php/jhsci/article/view/163>. Date accessed: 22 june 2018. doi: https://doi.org/10.17532/jhsci.2014.163.
Section
Research articles

Keywords

Prediabetes, Type2 Diabetes mellitus, costus igneus, streptozotocin, neonatal